Protein disulfide-isomerase A3 (PDIA3), also known as glucose-regulated protein, 58-kD (GRP58), is an isomerase enzyme encoded by the autosomal gene PDIA3 in humans. This protein localizes to the endoplasmic reticulum (ER) and interacts with lectin chaperones calreticulin and calnexin (CNX) to modulate folding of newly synthesized glycoproteins. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.
"}{"fact":"The average litter of kittens is between 2 - 6 kittens.","length":55}
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{"slip": { "id": 146, "advice": "Today, do not use the words \"Kind of\", \"Sort of\" or \"Maybe\". It either is or it isn't."}}
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